Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2551969..2553557 Replicon chromosome
Accession NZ_LR025101
Organism Escherichia coli isolate EC-1639

Toxin (Protein)


Gene name hipA Uniprot ID U9YVT8
Locus tag EC1639_RS12375 Protein ID WP_001125415.1
Coordinates 2551969..2553291 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EC1639_RS12380 Protein ID WP_001296726.1
Coordinates 2553291..2553557 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1639_RS12340 2547016..2547588 - 573 WP_000789914.1 NAD(P)H-dependent oxidoreductase -
EC1639_RS12345 2547738..2547929 - 192 WP_001306054.1 amidohydrolase family protein -
EC1639_RS12350 2547880..2548299 - 420 WP_001587057.1 amidohydrolase family protein -
EC1639_RS25925 2548259..2548414 - 156 WP_001327998.1 hypothetical protein -
EC1639_RS12355 2548517..2549464 - 948 WP_000854796.1 aldo/keto reductase -
EC1639_RS12360 2549526..2550215 - 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
EC1639_RS12365 2550224..2550532 - 309 WP_001221046.1 hypothetical protein -
EC1639_RS12370 2550672..2551571 + 900 WP_001057776.1 LysR family transcriptional regulator -
EC1639_RS12375 2551969..2553291 - 1323 WP_001125415.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
EC1639_RS12380 2553291..2553557 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EC1639_RS12385 2553768..2558533 - 4766 Protein_2356 autotransporter barrel domain-containing lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49384.05 Da        Isoelectric Point: 8.5830

>T285903 WP_001125415.1 NZ_LR025101:c2553291-2551969 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT285903 WP_001296726.1 NZ_LR025101:c2553557-2553291 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YVT8

Antitoxin

Source ID Structure

References