Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2455749..2456387 Replicon chromosome
Accession NZ_LR025101
Organism Escherichia coli isolate EC-1639

Toxin (Protein)


Gene name hicA Uniprot ID D3GRG9
Locus tag EC1639_RS11930 Protein ID WP_001314712.1
Coordinates 2455749..2455925 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EC1639_RS11935 Protein ID WP_077248684.1
Coordinates 2455971..2456387 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1639_RS11910 2451371..2452582 - 1212 WP_071593600.1 BenE family transporter YdcO -
EC1639_RS11915 2452635..2453171 + 537 WP_000429149.1 DNA-binding transcriptional regulator SutR -
EC1639_RS11920 2453244..2455205 + 1962 WP_001587031.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EC1639_RS11925 2455297..2455527 - 231 WP_000494241.1 YncJ family protein -
EC1639_RS11930 2455749..2455925 + 177 WP_001314712.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EC1639_RS11935 2455971..2456387 + 417 WP_077248684.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EC1639_RS11940 2456466..2457872 + 1407 WP_000760623.1 PLP-dependent aminotransferase family protein -
EC1639_RS11945 2458117..2459262 + 1146 WP_000047443.1 ABC transporter substrate-binding protein -
EC1639_RS11950 2459280..2460293 + 1014 WP_000220407.1 ABC transporter ATP-binding protein -
EC1639_RS11955 2460294..2461235 + 942 WP_001587036.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6746.81 Da        Isoelectric Point: 11.8888

>T285901 WP_001314712.1 NZ_LR025101:2455749-2455925 [Escherichia coli]
VKQSEFRRWLESQGVNVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15232.60 Da        Isoelectric Point: 4.7286

>AT285901 WP_077248684.1 NZ_LR025101:2455971-2456387 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSDITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GRG9

Antitoxin

Source ID Structure

References