Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1323720..1324338 Replicon chromosome
Accession NZ_LR025101
Organism Escherichia coli isolate EC-1639

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EC1639_RS06215 Protein ID WP_001291435.1
Coordinates 1323720..1323938 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EC1639_RS06220 Protein ID WP_000344800.1
Coordinates 1323964..1324338 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1639_RS06180 1319009..1319581 + 573 WP_000779833.1 YbaY family lipoprotein -
EC1639_RS06185 1319612..1319923 - 312 WP_000409911.1 MGMT family protein -
EC1639_RS06195 1320302..1320655 + 354 WP_000878140.1 DUF1428 domain-containing protein -
EC1639_RS06200 1320697..1322247 - 1551 WP_001305493.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EC1639_RS06205 1322411..1322881 - 471 WP_000136192.1 YlaC family protein -
EC1639_RS06210 1322997..1323548 - 552 WP_000102564.1 maltose O-acetyltransferase -
EC1639_RS06215 1323720..1323938 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EC1639_RS06220 1323964..1324338 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EC1639_RS06225 1324884..1328033 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
EC1639_RS06230 1328056..1329249 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T285891 WP_001291435.1 NZ_LR025101:c1323938-1323720 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT285891 WP_000344800.1 NZ_LR025101:c1324338-1323964 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References