Detailed information of TA system TA285890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1124737..1126390
• Replicon: chromosome
• Accession: NZ_LR025101
• Organism: Escherichia coli isolate EC-1639

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A0X5EJM1
• Locus tag: EC1639_RS05290
• Protein ID: WP_001615045.1
• Coordinates: 1125506..1126390 (+)
• Length: 295 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: EC1639_RS05285
• Protein ID: WP_001134467.1
• Coordinates: 1124737..1125519 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EC1639_RS05260	1120190..1121515	-	1326	WP_001586702.1	DNA phosphorothioation-dependent restriction protein DptG	-
EC1639_RS05265	1121520..1123169	-	1650	WP_001586703.1	DNA phosphorothioation-dependent restriction protein DptF	-
EC1639_RS05270	1123446..1123670	-	225	WP_024187424.1	helix-turn-helix domain-containing protein	-
EC1639_RS05275	1123751..1123981	-	231	WP_001577779.1	helix-turn-helix domain-containing protein	-
EC1639_RS05280	1124050..1124360	+	311	Protein_991	helix-turn-helix domain-containing protein	-
EC1639_RS05285	1124737..1125519	+	783	WP_001134467.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EC1639_RS05290	1125506..1126390	+	885	WP_001615045.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EC1639_RS05300	1126842..1127726	-	885	WP_001119037.1	LysR family transcriptional regulator	-
EC1639_RS05305	1127991..1129049	+	1059	WP_001586705.1	alpha/beta hydrolase	-
EC1639_RS05310	1129191..1130318	+	1128	WP_000171079.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	1113051..1167552	54501

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-209)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 295 a.a.
• Molecular weight: 33151.42 Da
• Isoelectric Point: 7.7408

>T285890 WP_001615045.1 NZ_LR025101:1125506-1126390 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAAINDALKRITASLNGRPGITAIRQENKA
DEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQHPRDLFDVLNMLE
KPGVMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQALKSHLTDLDREFS
LSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 885 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29093.39 Da
• Isoelectric Point: 8.4395

>AT285890 WP_001134467.1 NZ_LR025101:1124737-1125519 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSLTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A0X5EJM1