Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4506363..4507020 Replicon chromosome
Accession NZ_LR025099
Organism Klebsiella pneumoniae isolate EC-12536

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EC12536_RS22315 Protein ID WP_002916310.1
Coordinates 4506363..4506773 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EC12536_RS22320 Protein ID WP_002916312.1
Coordinates 4506754..4507020 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC12536_RS22295 4502363..4504096 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
EC12536_RS22300 4504102..4504815 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EC12536_RS22305 4504838..4505734 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EC12536_RS22310 4505835..4506356 + 522 WP_004144730.1 flavodoxin FldB -
EC12536_RS22315 4506363..4506773 - 411 WP_002916310.1 protein YgfX Toxin
EC12536_RS22320 4506754..4507020 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EC12536_RS22325 4507266..4508249 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
EC12536_RS22330 4508400..4509059 - 660 WP_002916317.1 hemolysin III family protein -
EC12536_RS22335 4509223..4509534 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EC12536_RS22340 4509584..4510312 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
EC12536_RS22345 4510431..4511864 + 1434 WP_004174453.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T285881 WP_002916310.1 NZ_LR025099:c4506773-4506363 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT285881 WP_002916312.1 NZ_LR025099:c4507020-4506754 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References