Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2750083..2751671 Replicon chromosome
Accession NZ_LR025099
Organism Klebsiella pneumoniae isolate EC-12536

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag EC12536_RS13655 Protein ID WP_004199851.1
Coordinates 2750349..2751671 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag EC12536_RS13650 Protein ID WP_002904790.1
Coordinates 2750083..2750349 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC12536_RS13625 2745233..2746156 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
EC12536_RS13630 2746137..2747291 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
EC12536_RS13635 2747637..2749016 + 1380 WP_004179808.1 purine permease -
EC12536_RS13640 2748994..2749494 + 501 WP_134156127.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EC12536_RS13645 2749491..2749817 + 327 WP_002904788.1 hydroxyisourate hydrolase -
EC12536_RS13650 2750083..2750349 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EC12536_RS13655 2750349..2751671 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
EC12536_RS13660 2751688..2752980 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
EC12536_RS13665 2753113..2754117 - 1005 WP_134156130.1 type 1 fimbrial protein -
EC12536_RS13670 2754105..2756606 - 2502 WP_134156133.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T285876 WP_004199851.1 NZ_LR025099:2750349-2751671 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT285876 WP_002904790.1 NZ_LR025099:2750083-2750349 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References