Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 593770..594286 Replicon chromosome
Accession NZ_LR025099
Organism Klebsiella pneumoniae isolate EC-12536

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag EC12536_RS02935 Protein ID WP_002886902.1
Coordinates 594002..594286 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag EC12536_RS02930 Protein ID WP_002886901.1
Coordinates 593770..594012 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC12536_RS02915 589798..590538 + 741 WP_004186692.1 KDGP aldolase family protein -
EC12536_RS02920 590605..591759 + 1155 WP_002886900.1 lactonase family protein -
EC12536_RS02925 591782..593692 + 1911 WP_004152270.1 BglG family transcription antiterminator -
EC12536_RS02930 593770..594012 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EC12536_RS02935 594002..594286 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EC12536_RS02940 594290..594754 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EC12536_RS02945 594995..597133 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
EC12536_RS02950 597490..598233 - 744 WP_040188479.1 MurR/RpiR family transcriptional regulator -
EC12536_RS26950 598236..598409 - 174 WP_002886906.1 hypothetical protein -
EC12536_RS02955 598494..598802 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T285873 WP_002886902.1 NZ_LR025099:594002-594286 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT285873 WP_002886901.1 NZ_LR025099:593770-594012 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References