Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 432260..433941 Replicon chromosome
Accession NZ_LR025099
Organism Klebsiella pneumoniae isolate EC-12536

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag EC12536_RS02100 Protein ID WP_023328808.1
Coordinates 433024..433941 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag EC12536_RS02095 Protein ID WP_004177809.1
Coordinates 432260..433018 (+) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC12536_RS02080 428110..428796 - 687 WP_004151733.1 sel1 repeat family protein -
EC12536_RS02085 429026..431173 - 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
EC12536_RS02090 431446..432174 + 729 WP_004177810.1 response regulator transcription factor -
EC12536_RS02095 432260..433018 + 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
EC12536_RS02100 433024..433941 + 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
EC12536_RS02105 434066..435073 - 1008 WP_004178300.1 carbohydrate kinase family protein -
EC12536_RS02110 435148..436089 - 942 WP_002885156.1 ABC transporter substrate-binding protein -
EC12536_RS02115 436120..437118 - 999 WP_004872882.1 ribose ABC transporter permease -
EC12536_RS02120 437115..438635 - 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T285872 WP_023328808.1 NZ_LR025099:433024-433941 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT285872 WP_004177809.1 NZ_LR025099:432260-433018 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References