Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 78800..79425 Replicon chromosome
Accession NZ_LR025099
Organism Klebsiella pneumoniae isolate EC-12536

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag EC12536_RS00390 Protein ID WP_002882817.1
Coordinates 79042..79425 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EC12536_RS00385 Protein ID WP_172601897.1
Coordinates 78800..79042 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC12536_RS00360 74791..75390 + 600 WP_004151865.1 glucose-1-phosphatase -
EC12536_RS00365 75384..76244 + 861 WP_004146232.1 virulence factor BrkB family protein -
EC12536_RS00370 76241..76678 + 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
EC12536_RS00375 76723..77664 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
EC12536_RS00380 77678..78595 - 918 WP_004178029.1 alpha/beta hydrolase -
EC12536_RS00385 78800..79042 + 243 WP_172601897.1 ribbon-helix-helix domain-containing protein Antitoxin
EC12536_RS00390 79042..79425 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
EC12536_RS00395 79599..80528 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
EC12536_RS00400 80525..81160 - 636 WP_134155443.1 formate dehydrogenase cytochrome b556 subunit -
EC12536_RS00405 81157..82059 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T285871 WP_002882817.1 NZ_LR025099:79042-79425 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9514.78 Da        Isoelectric Point: 4.2500

>AT285871 WP_172601897.1 NZ_LR025099:78800-79042 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQCQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure

References