Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4783993..4784660 Replicon chromosome
Accession NZ_LR025096
Organism Escherichia coli isolate EC-7215

Toxin (Protein)


Gene name ypjF Uniprot ID E1IS66
Locus tag EC7215_RS23195 Protein ID WP_000856973.1
Coordinates 4784340..4784660 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID E1IS67
Locus tag EC7215_RS23190 Protein ID WP_000052843.1
Coordinates 4783993..4784319 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC7215_RS23160 4779505..4780194 + 690 WP_000115588.1 WYL domain-containing protein -
EC7215_RS23165 4780256..4781266 + 1011 WP_001348677.1 hypothetical protein -
EC7215_RS23175 4781505..4782682 + 1178 WP_085968792.1 IS3 family transposase -
EC7215_RS23180 4782704..4783441 + 738 Protein_4456 DUF932 domain-containing protein -
EC7215_RS23185 4783510..4783980 + 471 WP_001275770.1 DNA repair protein RadC -
EC7215_RS23190 4783993..4784319 + 327 WP_000052843.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC7215_RS23195 4784340..4784660 + 321 WP_000856973.1 TA system toxin CbtA family protein Toxin
EC7215_RS23205 4785427..4786611 + 1185 WP_001172876.1 sugar efflux transporter -
EC7215_RS23210 4786722..4787645 + 924 WP_000535971.1 carboxylate/amino acid/amine transporter -
EC7215_RS23215 4787649..4788467 - 819 WP_000779426.1 lipoprotein NlpA -
EC7215_RS23220 4788689..4788982 + 294 WP_000805509.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12080.87 Da        Isoelectric Point: 5.5873

>T285865 WP_000856973.1 NZ_LR025096:4784340-4784660 [Escherichia coli]
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12305.01 Da        Isoelectric Point: 6.3620

>AT285865 WP_000052843.1 NZ_LR025096:4783993-4784319 [Escherichia coli]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345ENE3

Antitoxin

Source ID Structure
AlphaFold DB A0A345ENE4

References