285861

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3500776..3501401 Replicon chromosome
Accession NZ_LR025096
Organism Escherichia coli isolate EC-7215

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag EC7215_RS16930 Protein ID WP_000911329.1
Coordinates 3500776..3501174 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EC7215_RS16935 Protein ID WP_000450524.1
Coordinates 3501174..3501401 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC7215_RS16910 3496654..3496854 + 201 WP_000383836.1 YpfN family protein -
EC7215_RS16915 3496964..3497662 - 699 WP_000679812.1 esterase -
EC7215_RS16920 3497736..3499751 - 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
EC7215_RS16925 3499766..3500629 - 864 WP_001267507.1 neutral zinc metallopeptidase -
EC7215_RS16930 3500776..3501174 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
EC7215_RS16935 3501174..3501401 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EC7215_RS16940 3501557..3502270 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EC7215_RS16945 3502483..3503517 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EC7215_RS16950 3503534..3504412 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EC7215_RS16955 3504558..3505130 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EC7215_RS16960 3505130..3505600 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T285861 WP_000911329.1 NZ_LR025096:c3501174-3500776 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT285861 WP_000450524.1 NZ_LR025096:c3501401-3501174 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References