Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2329103..2329741 Replicon chromosome
Accession NZ_LR025096
Organism Escherichia coli isolate EC-7215

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EC7215_RS11220 Protein ID WP_000813794.1
Coordinates 2329103..2329279 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EC7215_RS11225 Protein ID WP_001270286.1
Coordinates 2329325..2329741 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC7215_RS11200 2324722..2325936 - 1215 WP_001307190.1 BenE family transporter YdcO -
EC7215_RS11205 2325989..2326525 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
EC7215_RS11210 2326598..2328559 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EC7215_RS11215 2328651..2328881 - 231 WP_000494244.1 YncJ family protein -
EC7215_RS11220 2329103..2329279 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EC7215_RS11225 2329325..2329741 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EC7215_RS11230 2329820..2331226 + 1407 WP_000760589.1 PLP-dependent aminotransferase family protein -
EC7215_RS11235 2331471..2332616 + 1146 WP_000047455.1 ABC transporter substrate-binding protein -
EC7215_RS11240 2332634..2333647 + 1014 WP_000220416.1 ABC transporter ATP-binding protein -
EC7215_RS11245 2333648..2334589 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2323417..2324682 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T285855 WP_000813794.1 NZ_LR025096:2329103-2329279 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT285855 WP_001270286.1 NZ_LR025096:2329325-2329741 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References