Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1283619..1284237 Replicon chromosome
Accession NZ_LR025096
Organism Escherichia coli isolate EC-7215

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EC7215_RS06040 Protein ID WP_001291435.1
Coordinates 1283619..1283837 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EC7215_RS06045 Protein ID WP_000344800.1
Coordinates 1283863..1284237 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC7215_RS06005 1278908..1279480 + 573 WP_000779839.1 YbaY family lipoprotein -
EC7215_RS06010 1279511..1279822 - 312 WP_000409911.1 MGMT family protein -
EC7215_RS06020 1280201..1280554 + 354 WP_000878141.1 DUF1428 family protein -
EC7215_RS06025 1280596..1282146 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EC7215_RS06030 1282310..1282780 - 471 WP_000136192.1 YlaC family protein -
EC7215_RS06035 1282896..1283447 - 552 WP_000102564.1 maltose O-acetyltransferase -
EC7215_RS06040 1283619..1283837 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EC7215_RS06045 1283863..1284237 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EC7215_RS06050 1284783..1287932 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EC7215_RS06055 1287955..1289148 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T285854 WP_001291435.1 NZ_LR025096:c1283837-1283619 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT285854 WP_000344800.1 NZ_LR025096:c1284237-1283863 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References