Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 588295..588890 Replicon chromosome
Accession NZ_LR025096
Organism Escherichia coli isolate EC-7215

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag EC7215_RS02785 Protein ID WP_000239579.1
Coordinates 588540..588890 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag EC7215_RS02780 Protein ID WP_001223208.1
Coordinates 588295..588546 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC7215_RS02770 583959..587738 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
EC7215_RS02775 587741..588082 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
EC7215_RS02780 588295..588546 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
EC7215_RS02785 588540..588890 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
EC7215_RS02790 588970..589500 - 531 WP_000055072.1 inorganic diphosphatase -
EC7215_RS02795 589810..590766 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
EC7215_RS02800 591076..592578 + 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
EC7215_RS02805 592592..593614 + 1023 WP_024198507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T285850 WP_000239579.1 NZ_LR025096:588540-588890 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT285850 WP_001223208.1 NZ_LR025096:588295-588546 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References