Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3964303..3964960 Replicon chromosome
Accession NZ_LR025092
Organism Klebsiella pneumoniae isolate KP9201

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KP920_RS19870 Protein ID WP_002916310.1
Coordinates 3964303..3964713 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KP920_RS19875 Protein ID WP_002916312.1
Coordinates 3964694..3964960 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP920_RS19850 3960303..3962036 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KP920_RS19855 3962042..3962755 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KP920_RS19860 3962778..3963674 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KP920_RS19865 3963775..3964296 + 522 WP_004144730.1 flavodoxin FldB -
KP920_RS19870 3964303..3964713 - 411 WP_002916310.1 protein YgfX Toxin
KP920_RS19875 3964694..3964960 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KP920_RS19880 3965206..3966189 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
KP920_RS19885 3966340..3966999 - 660 WP_002916317.1 hemolysin III family protein -
KP920_RS19890 3967163..3967474 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KP920_RS19895 3967524..3968252 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KP920_RS19900 3968371..3969804 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T285840 WP_002916310.1 NZ_LR025092:c3964713-3964303 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT285840 WP_002916312.1 NZ_LR025092:c3964960-3964694 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References