Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2188039..2189627 Replicon chromosome
Accession NZ_LR025092
Organism Klebsiella pneumoniae isolate KP9201

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag KP920_RS10965 Protein ID WP_023301940.1
Coordinates 2188305..2189627 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KP920_RS10960 Protein ID WP_002904790.1
Coordinates 2188039..2188305 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP920_RS10935 2183189..2184112 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
KP920_RS10940 2184093..2185247 - 1155 WP_040182036.1 FAD-dependent urate hydroxylase HpxO -
KP920_RS10945 2185593..2186972 + 1380 WP_004176204.1 purine permease -
KP920_RS10950 2186950..2187450 + 501 WP_040182039.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KP920_RS10955 2187447..2187773 + 327 WP_004143476.1 hydroxyisourate hydrolase -
KP920_RS10960 2188039..2188305 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KP920_RS10965 2188305..2189627 + 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
KP920_RS10970 2189644..2190936 - 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
KP920_RS10980 2191078..2192082 - 1005 WP_009308876.1 type 1 fimbrial protein -
KP920_RS10985 2192070..2194571 - 2502 WP_040182042.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T285835 WP_023301940.1 NZ_LR025092:2188305-2189627 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT285835 WP_002904790.1 NZ_LR025092:2188039-2188305 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References