Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4986424..4987043 Replicon chromosome
Accession NZ_LR025088
Organism Klebsiella pneumoniae isolate KP980

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KP980_RS24890 Protein ID WP_002892050.1
Coordinates 4986424..4986642 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KP980_RS24895 Protein ID WP_002892066.1
Coordinates 4986669..4987043 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP980_RS24860 4982467..4982730 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KP980_RS24865 4982730..4982870 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KP980_RS24870 4982867..4983565 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
KP980_RS24875 4983666..4985117 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KP980_RS24880 4985092..4985562 - 471 WP_040182126.1 YlaC family protein -
KP980_RS29055 4985583..4985723 + 141 WP_004147370.1 hypothetical protein -
KP980_RS24885 4985695..4986261 - 567 WP_002892030.1 maltose O-acetyltransferase -
KP980_RS24890 4986424..4986642 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
KP980_RS24895 4986669..4987043 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KP980_RS24900 4987529..4990675 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KP980_RS24905 4990698..4991891 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T285828 WP_002892050.1 NZ_LR025088:c4986642-4986424 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT285828 WP_002892066.1 NZ_LR025088:c4987043-4986669 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References