Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4368605..4369418 Replicon chromosome
Accession NZ_LR025088
Organism Klebsiella pneumoniae isolate KP980

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag KP980_RS21875 Protein ID WP_101516303.1
Coordinates 4368882..4369418 (+) Length 179 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag KP980_RS21870 Protein ID WP_023343051.1
Coordinates 4368605..4368871 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP980_RS21850 4364476..4364820 - 345 WP_004192220.1 cation efflux system protein CusF -
KP980_RS21855 4364838..4366223 - 1386 WP_040182471.1 efflux transporter outer membrane subunit -
KP980_RS21860 4366396..4367079 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
KP980_RS21865 4367069..4368502 + 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
KP980_RS21870 4368605..4368871 + 267 WP_023343051.1 DUF1778 domain-containing protein Antitoxin
KP980_RS21875 4368882..4369418 + 537 WP_101516303.1 GNAT family N-acetyltransferase Toxin
KP980_RS21880 4369466..4370587 - 1122 WP_012737335.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 19951.87 Da        Isoelectric Point: 5.7068

>T285827 WP_101516303.1 NZ_LR025088:4368882-4369418 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSN
LLFYPTKSIEQLFTDDES

Download         Length: 537 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT285827 WP_023343051.1 NZ_LR025088:4368605-4368871 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References