Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4283615..4284131 Replicon chromosome
Accession NZ_LR025088
Organism Klebsiella pneumoniae isolate KP980

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KP980_RS21470 Protein ID WP_002886902.1
Coordinates 4283847..4284131 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KP980_RS21465 Protein ID WP_002886901.1
Coordinates 4283615..4283857 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP980_RS21450 4279643..4280383 + 741 WP_002886899.1 KDGP aldolase family protein -
KP980_RS21455 4280450..4281604 + 1155 WP_023302389.1 lactonase family protein -
KP980_RS21460 4281627..4283537 + 1911 WP_009486549.1 BglG family transcription antiterminator -
KP980_RS21465 4283615..4283857 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KP980_RS21470 4283847..4284131 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KP980_RS21475 4284135..4284599 - 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KP980_RS21480 4284908..4287046 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KP980_RS21485 4287403..4288146 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
KP980_RS28935 4288149..4288322 - 174 WP_032410138.1 hypothetical protein -
KP980_RS21490 4288407..4288715 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T285826 WP_002886902.1 NZ_LR025088:4283847-4284131 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT285826 WP_002886901.1 NZ_LR025088:4283615-4283857 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References