Detailed information of TA system TA285825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4121788..4123469
• Replicon: chromosome
• Accession: NZ_LR025088
• Organism: Klebsiella pneumoniae isolate KP980

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: KP980_RS20650
• Protein ID: WP_004146663.1
• Coordinates: 4122552..4123469 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: KP980_RS20645
• Protein ID: WP_004177809.1
• Coordinates: 4121788..4122546 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP980_RS20630	4117638..4118324	-	687	WP_004151733.1	sel1 repeat family protein	-
KP980_RS20635	4118554..4120701	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KP980_RS20640	4120974..4121702	+	729	WP_004177810.1	response regulator transcription factor	-
KP980_RS20645	4121788..4122546	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KP980_RS20650	4122552..4123469	+	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KP980_RS20655	4123594..4124601	-	1008	WP_004178300.1	carbohydrate kinase family protein	-
KP980_RS20660	4124676..4125617	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
KP980_RS20665	4125648..4126646	-	999	WP_012737175.1	ribose ABC transporter permease	-
KP980_RS20670	4126643..4128163	-	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T285825 WP_004146663.1 NZ_LR025088:4122552-4123469 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT285825 WP_004177809.1 NZ_LR025088:4121788-4122546 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05