Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3804467..3805092 Replicon chromosome
Accession NZ_LR025088
Organism Klebsiella pneumoniae isolate KP980

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KP980_RS19125 Protein ID WP_040182550.1
Coordinates 3804709..3805092 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag KP980_RS19120 Protein ID WP_004150355.1
Coordinates 3804467..3804709 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP980_RS19095 3800458..3801057 + 600 WP_004151865.1 glucose-1-phosphatase -
KP980_RS19100 3801051..3801911 + 861 WP_004146232.1 virulence factor BrkB family protein -
KP980_RS19105 3801908..3802345 + 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
KP980_RS19110 3802390..3803331 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
KP980_RS19115 3803345..3804262 - 918 WP_023302328.1 alpha/beta hydrolase -
KP980_RS19120 3804467..3804709 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
KP980_RS19125 3804709..3805092 + 384 WP_040182550.1 type II toxin-antitoxin system VapC family toxin Toxin
KP980_RS19130 3805266..3806195 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
KP980_RS19135 3806192..3806827 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
KP980_RS19140 3806824..3807726 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14376.67 Da        Isoelectric Point: 9.5352

>T285824 WP_040182550.1 NZ_LR025088:3804709-3805092 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLKLITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT285824 WP_004150355.1 NZ_LR025088:3804467-3804709 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References