Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 484460..485031 Replicon chromosome
Accession NZ_LN999987
Organism Enterococcus faecium isolate EFE11651

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag EFE1165_RS02475 Protein ID WP_002286801.1
Coordinates 484690..485031 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag EFE1165_RS02470 Protein ID WP_002323011.1
Coordinates 484460..484690 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFE1165_RS02420 479593..480924 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
EFE1165_RS02425 480946..481572 + 627 WP_002286816.1 cysteine hydrolase -
EFE1165_RS02430 481755..482336 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
EFE1165_RS02450 483068..483415 + 348 WP_002286808.1 SOS response-associated peptidase family protein -
EFE1165_RS02455 483391..483630 + 240 WP_002321938.1 SOS response-associated peptidase family protein -
EFE1165_RS02460 483835..484173 - 339 WP_002286804.1 hypothetical protein -
EFE1165_RS02470 484460..484690 + 231 WP_002323011.1 hypothetical protein Antitoxin
EFE1165_RS02475 484690..485031 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EFE1165_RS02480 485881..486066 + 186 WP_002304207.1 hypothetical protein -
EFE1165_RS02485 486571..486765 + 195 WP_002297028.1 hypothetical protein -
EFE1165_RS02490 486923..487205 + 283 Protein_463 transposase -
EFE1165_RS02500 487449..488279 - 831 WP_002286789.1 manganese catalase family protein -
EFE1165_RS02505 488487..489821 + 1335 WP_002286788.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T285813 WP_002286801.1 NZ_LN999987:484690-485031 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT285813 WP_002323011.1 NZ_LN999987:484460-484690 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References