Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 20096..20621 Replicon plasmid pSLT
Accession NZ_LN999012
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. DT2

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag STMDT2_RS23385 Protein ID WP_001159863.1
Coordinates 20316..20621 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag STMDT2_RS23380 Protein ID WP_000813641.1
Coordinates 20096..20314 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STMDT2_RS23355 15383..15764 + 382 Protein_20 YgiW/YdeI family stress tolerance OB fold protein -
STMDT2_RS26005 15933..16377 + 445 Protein_21 site-specific integrase -
STMDT2_RS23365 16636..17625 - 990 WP_001527061.1 RepB family plasmid replication initiator protein -
STMDT2_RS25710 18119..18415 - 297 WP_001687482.1 hypothetical protein -
STMDT2_RS23375 18899..19420 - 522 WP_010999942.1 hypothetical protein -
STMDT2_RS23380 20096..20314 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
STMDT2_RS23385 20316..20621 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
STMDT2_RS23390 20623..20913 + 291 WP_001266176.1 hypothetical protein -
STMDT2_RS23395 20910..21431 + 522 WP_000198608.1 hypothetical protein -
STMDT2_RS23400 21466..22248 + 783 WP_000082169.1 site-specific integrase -
STMDT2_RS23405 22257..22970 + 714 Protein_30 EAL domain-containing protein -
STMDT2_RS23410 22974..23483 + 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
STMDT2_RS23415 23477..23962 + 486 WP_063977669.1 hypothetical protein -
STMDT2_RS26010 24239..24526 - 288 WP_071530243.1 hypothetical protein -
STMDT2_RS23425 24682..25242 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93844 93844


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T285807 WP_001159863.1 NZ_LN999012:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium str. DT2]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT285807 WP_000813641.1 NZ_LN999012:20096-20314 [Salmonella enterica subsp. enterica serovar Typhimurium str. DT2]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References