Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 396403..397000 Replicon chromosome
Accession NZ_LN999010
Organism Thermococcus chitonophagus isolate

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CHITON_RS02150 Protein ID WP_084448844.1
Coordinates 396403..396792 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A160VU82
Locus tag CHITON_RS02155 Protein ID WP_068576321.1
Coordinates 396779..397000 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHITON_RS02130 (CHITON_0427) 391960..393240 + 1281 Protein_431 argininosuccinate lyase -
CHITON_RS02135 (CHITON_0428) 393249..394073 + 825 WP_068576315.1 lysine biosynthesis protein LysX -
CHITON_RS02140 (CHITON_0429) 394070..395674 - 1605 WP_068576317.1 radical SAM protein -
CHITON_RS02145 (CHITON_0430) 395814..396434 + 621 WP_068576318.1 METTL5 family protein -
CHITON_RS02150 (CHITON_0431) 396403..396792 - 390 WP_084448844.1 type II toxin-antitoxin system VapC family toxin Toxin
CHITON_RS02155 (CHITON_0432) 396779..397000 - 222 WP_068576321.1 hypothetical protein Antitoxin
CHITON_RS02160 (CHITON_0433) 397042..399369 - 2328 WP_068576323.1 DNA polymerase -
CHITON_RS02165 (CHITON_0434) 399464..400276 + 813 WP_068576325.1 MBL fold metallo-hydrolase -
CHITON_RS02170 (CHITON_0435) 400273..401013 - 741 WP_068576327.1 ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14595.96 Da        Isoelectric Point: 4.7712

>T285805 WP_084448844.1 NZ_LN999010:c396792-396403 [Thermococcus chitonophagus]
VIVIDASALVMVVLQEPGWEKVPIGSEVATLDYAYVEGMNAIWKAVRWRELTREQGRMKITVLRMMKSSITTYRTEDFFE
RGLEIALDEGIAVYDAFYIALAESLDAKLVTADEKQYKAAKNYVPAKLV

Download         Length: 390 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8710.98 Da        Isoelectric Point: 9.7232

>AT285805 WP_068576321.1 NZ_LN999010:c397000-396779 [Thermococcus chitonophagus]
MAVLSIRIPDELKEKMKEFDINWSEEIRRFIKERIEYEERKRTLEKALELAKKSGSVSKGFSARAVREDRDSH

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A160VU82

References