Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/-
Location 3466447..3467100 Replicon chromosome
Accession NZ_LN997846
Organism Acinetobacter baumannii isolate R2091

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag ABR2091_RS16110 Protein ID WP_000607075.1
Coordinates 3466447..3466836 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag ABR2091_RS16115 Protein ID WP_001288210.1
Coordinates 3466843..3467100 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABR2091_RS16095 3461565..3463760 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
ABR2091_RS16100 3463948..3464514 - 567 WP_000651536.1 rhombosortase -
ABR2091_RS16105 3464592..3465677 - 1086 WP_000049106.1 hypothetical protein -
ABR2091_RS16110 3466447..3466836 - 390 WP_000607075.1 membrane protein Toxin
ABR2091_RS16115 3466843..3467100 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
ABR2091_RS16120 3467288..3468460 + 1173 WP_032028213.1 acyl-CoA dehydrogenase family protein -
ABR2091_RS16125 3468509..3469999 - 1491 WP_031966421.1 NAD(P)/FAD-dependent oxidoreductase -
ABR2091_RS16130 3470181..3470558 - 378 WP_001216380.1 50S ribosomal protein L17 -
ABR2091_RS16135 3470577..3471584 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(10-82)


Sequences


Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T285801 WP_000607075.1 NZ_LN997846:c3466836-3466447 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT285801 WP_001288210.1 NZ_LN997846:c3467100-3466843 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3R9G864


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References