Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2110280..2110995 Replicon chromosome
Accession NZ_LN908249
Organism Actinobacillus pleuropneumoniae serovar 8 isolate MIDG2331

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIDG2331_RS10025 Protein ID WP_039709408.1
Coordinates 2110280..2110708 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BT01
Locus tag MIDG2331_RS10030 Protein ID WP_005599447.1
Coordinates 2110708..2110995 (-) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIDG2331_RS10010 2105865..2107571 - 1707 WP_005609259.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
MIDG2331_RS10015 2107667..2107948 - 282 WP_012263402.1 DNA-directed RNA polymerase subunit omega -
MIDG2331_RS10020 2108075..2110156 - 2082 WP_039709407.1 ATP-dependent DNA helicase RecG -
MIDG2331_RS10025 2110280..2110708 - 429 WP_039709408.1 type II toxin-antitoxin system VapC family toxin Toxin
MIDG2331_RS10030 2110708..2110995 - 288 WP_005599447.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MIDG2331_RS10035 2111201..2112916 + 1716 WP_039709409.1 proline--tRNA ligase -
MIDG2331_RS10040 2112982..2113170 - 189 WP_005602684.1 hypothetical protein -
MIDG2331_RS10045 2113173..2113754 - 582 WP_005606496.1 sigma-70 family RNA polymerase sigma factor -
MIDG2331_RS10050 2113843..2114799 + 957 WP_005619040.1 protein-methionine-sulfoxide reductase catalytic subunit MsrP -
MIDG2331_RS10055 2114799..2115392 + 594 WP_005599453.1 sulfoxide reductase heme-binding subunit YedZ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-130)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 143 a.a.        Molecular weight: 16549.96 Da        Isoelectric Point: 7.8935

>T285800 WP_039709408.1 NZ_LN908249:c2110708-2110280 [Actinobacillus pleuropneumoniae serovar 8]
MFQYLFDTNIISELYKLGNSRIDTNVRQWLETIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHDVLSVYQA
KSFSINNEIALLASEYHIPNKMDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Download         Length: 429 bp


Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11040.29 Da        Isoelectric Point: 4.5578

>AT285800 WP_005599447.1 NZ_LN908249:c2110995-2110708 [Actinobacillus pleuropneumoniae serovar 8]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Download         Length: 288 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A3N3C5

References