Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2014453..2015081 Replicon chromosome
Accession NZ_LN908249
Organism Actinobacillus pleuropneumoniae serovar 8 isolate MIDG2331

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MIDG2331_RS09440 Protein ID WP_005609156.1
Coordinates 2014683..2015081 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MIDG2331_RS09435 Protein ID WP_039709385.1
Coordinates 2014453..2014683 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIDG2331_RS09430 2012302..2013933 + 1632 WP_005613299.1 hypothetical protein -
MIDG2331_RS11540 2014205..2014345 - 141 WP_162835170.1 hypothetical protein -
MIDG2331_RS09435 2014453..2014683 + 231 WP_039709385.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MIDG2331_RS09440 2014683..2015081 + 399 WP_005609156.1 tRNA(fMet)-specific endonuclease VapC Toxin
MIDG2331_RS09445 2015216..2015632 - 417 WP_005609158.1 DUF417 family protein -
MIDG2331_RS09450 2015879..2016529 + 651 WP_039709386.1 DUF2202 domain-containing protein -
MIDG2331_RS09455 2016604..2017263 - 660 WP_039709387.1 hypothetical protein -
MIDG2331_RS11545 2017509..2017670 - 162 WP_160260668.1 hypothetical protein -
MIDG2331_RS09460 2017663..2018334 - 672 WP_039709388.1 hypothetical protein -
MIDG2331_RS09465 2018406..2019728 - 1323 WP_039709389.1 HslU--HslV peptidase ATPase subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1998958..2030905 31947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15066.37 Da        Isoelectric Point: 7.3824

>T285799 WP_005609156.1 NZ_LN908249:2014683-2015081 [Actinobacillus pleuropneumoniae serovar 8]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKCGKILGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8581.65 Da        Isoelectric Point: 4.5203

>AT285799 WP_039709385.1 NZ_LN908249:2014453-2014683 [Actinobacillus pleuropneumoniae serovar 8]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References