Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1796808..1797539 Replicon chromosome
Accession NZ_LN908249
Organism Actinobacillus pleuropneumoniae serovar 8 isolate MIDG2331

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MIDG2331_RS08365 Protein ID WP_005598840.1
Coordinates 1796808..1797275 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag MIDG2331_RS08370 Protein ID WP_005619269.1
Coordinates 1797279..1797539 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIDG2331_RS08340 1792168..1792539 - 372 WP_005598830.1 CrcB family protein -
MIDG2331_RS08345 1792542..1793606 - 1065 WP_039709309.1 MFS transporter -
MIDG2331_RS08350 1793701..1794810 + 1110 WP_039709310.1 anhydro-N-acetylmuramic acid kinase -
MIDG2331_RS08355 1794863..1795777 + 915 WP_005598836.1 N-acetylmuramic acid 6-phosphate etherase -
MIDG2331_RS08360 1795844..1796725 - 882 WP_005598838.1 50S ribosomal protein L11 methyltransferase -
MIDG2331_RS08365 1796808..1797275 - 468 WP_005598840.1 GNAT family N-acetyltransferase Toxin
MIDG2331_RS08370 1797279..1797539 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
MIDG2331_RS08375 1797660..1799120 - 1461 WP_039709592.1 metalloprotease TldD -
MIDG2331_RS08380 1799250..1800509 + 1260 WP_039709311.1 tRNA lysidine(34) synthetase TilS -
MIDG2331_RS08385 1800536..1800826 - 291 WP_005602215.1 DUF5389 family protein -
MIDG2331_RS08390 1800828..1801721 - 894 WP_005598850.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17206.22 Da        Isoelectric Point: 8.9312

>T285798 WP_005598840.1 NZ_LN908249:c1797275-1796808 [Actinobacillus pleuropneumoniae serovar 8]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGIKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT285798 WP_005619269.1 NZ_LN908249:c1797539-1797279 [Actinobacillus pleuropneumoniae serovar 8]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References