Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 729866..730516 Replicon chromosome
Accession NZ_LN908249
Organism Actinobacillus pleuropneumoniae serovar 8 isolate MIDG2331

Toxin (Protein)


Gene name vapC Uniprot ID B0BNU3
Locus tag MIDG2331_RS03310 Protein ID WP_005614926.1
Coordinates 729866..730255 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BNU4
Locus tag MIDG2331_RS03315 Protein ID WP_005604117.1
Coordinates 730256..730516 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MIDG2331_RS03295 725442..726632 + 1191 WP_171823688.1 aromatic amino acid transaminase -
MIDG2331_RS03300 726812..728098 - 1287 WP_009874699.1 Xaa-Pro aminopeptidase -
MIDG2331_RS03305 728507..729730 - 1224 WP_039709068.1 ATP-binding protein -
MIDG2331_RS03310 729866..730255 - 390 WP_005614926.1 type II toxin-antitoxin system VapC family toxin Toxin
MIDG2331_RS03315 730256..730516 - 261 WP_005604117.1 hypothetical protein Antitoxin
MIDG2331_RS03320 730650..732671 - 2022 WP_058230468.1 excinuclease ABC subunit B -
MIDG2331_RS03325 732848..733660 + 813 WP_039709069.1 EfeM/EfeO family lipoprotein -
MIDG2331_RS03330 733672..734865 + 1194 WP_005604123.1 deferrochelatase/peroxidase EfeB -
MIDG2331_RS03335 734876..735496 + 621 WP_039709071.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14837.17 Da        Isoelectric Point: 5.1295

>T285795 WP_005614926.1 NZ_LN908249:c730255-729866 [Actinobacillus pleuropneumoniae serovar 8]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQFIPNLVLENWWK

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.63 Da        Isoelectric Point: 5.1867

>AT285795 WP_005604117.1 NZ_LN908249:c730516-730256 [Actinobacillus pleuropneumoniae serovar 8]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N029

Antitoxin

Source ID Structure
AlphaFold DB A3N030

References