Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 516474..517554 Replicon chromosome
Accession NZ_LN907858
Organism Helicobacter typhlonius strain MIT 97-6810 isolate

Toxin (Protein)


Gene name Fic Uniprot ID A0A0S4PUS2
Locus tag BN2458_RS02580 Protein ID WP_052082038.1
Coordinates 516742..517554 (+) Length 271 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A4U8SJV8
Locus tag BN2458_RS02575 Protein ID WP_052082037.1
Coordinates 516474..516737 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN2458_RS02550 511778..512725 - 948 WP_034328254.1 pyruvate ferredoxin oxidoreductase -
BN2458_RS02555 512737..513957 - 1221 WP_034328256.1 2-oxoacid:ferredoxin oxidoreductase subunit alpha -
BN2458_RS02560 513974..514369 - 396 WP_034328258.1 4Fe-4S dicluster domain-containing protein -
BN2458_RS02565 514388..514948 - 561 WP_034328260.1 pyruvate flavodoxin oxidoreductase subunit gamma -
BN2458_RS09670 515282..515878 - 597 WP_081951395.1 DUF1311 domain-containing protein -
BN2458_RS09675 516097..516258 + 162 WP_161594504.1 zinc ribbon-containing protein -
BN2458_RS02575 516474..516737 + 264 WP_052082037.1 hypothetical protein Antitoxin
BN2458_RS02580 516742..517554 + 813 WP_052082038.1 Fic family protein Toxin
BN2458_RS02585 517819..518049 - 231 WP_034342178.1 hypothetical protein -
BN2458_RS02590 518046..519575 - 1530 WP_138117617.1 hypothetical protein -
BN2458_RS02595 520219..520524 + 306 WP_034328695.1 hypothetical protein -
BN2458_RS02600 520521..520784 + 264 WP_034342182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(53-157)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 271 a.a.        Molecular weight: 31661.88 Da        Isoelectric Point: 9.4302

>T285792 WP_052082038.1 NZ_LN907858:516742-517554 [Helicobacter typhlonius]
MWDSDEHLNDFDRFLLETNLVGATSLDELRHRERLLTLKRTQTLKTTYIKRDFSYKHLKAIHKHIFQDVYTWAGQDRYEM
GLYGFMSKGDSTFCKGSFLPKQSKNIFENLKQCSLHEKQKDVDTLAQNLTTFMTDLNALHPFREGNGRVQRIFINELAHN
AGFALDLNLIPKNDMIEASIQAMQGDNTELLKLIKTNLYSNTQAELQRRLDINLNNYGKVNDEKQKQEFLERANAIKEQT
KKFNITLDSKSLQRLERINQEQNKERGRGR

Download         Length: 813 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9942.13 Da        Isoelectric Point: 4.2828

>AT285792 WP_052082037.1 NZ_LN907858:516474-516737 [Helicobacter typhlonius]
MTAQVNVLATNNYPEAHSLEESLAILESYRNNLTETQYKSIRSNICNFAIEDMFANQQDIIELIQIEKGEKTADEIIAQH
KSQWGLL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4PUS2

Antitoxin

Source ID Structure
AlphaFold DB A0A4U8SJV8

References