Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 97401..97875 Replicon plasmid pEM02
Accession NZ_LN907829
Organism Erwinia gerundensis isolate E_g_EM595

Toxin (Protein)


Gene name pasB Uniprot ID A0A0U5L901
Locus tag EM595_RS20255 Protein ID WP_067437246.1
Coordinates 97609..97875 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0U5L7D9
Locus tag EM595_RS20250 Protein ID WP_067437243.1
Coordinates 97401..97625 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM595_RS20235 93594..94352 - 759 WP_067437238.1 ABC transporter ATP-binding protein -
EM595_RS20240 94349..95386 - 1038 WP_067437241.1 iron ABC transporter permease -
EM595_RS20245 95386..96386 - 1001 Protein_87 ABC transporter substrate-binding protein -
EM595_RS20250 97401..97625 + 225 WP_067437243.1 TraY domain-containing protein Antitoxin
EM595_RS20255 97609..97875 + 267 WP_067437246.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EM595_RS20260 98149..98817 + 669 WP_067437248.1 recombinase family protein -
EM595_RS20265 98798..99202 + 405 WP_067437253.1 hypothetical protein -
EM595_RS20270 99229..100737 - 1509 WP_067437256.1 conjugal transfer protein TraG N-terminal domain-containing protein -
EM595_RS20275 100737..101102 - 366 WP_067437259.1 hypothetical protein -
EM595_RS20280 101117..102571 - 1455 WP_067437262.1 integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..134943 134943


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10356.94 Da        Isoelectric Point: 9.5211

>T285791 WP_067437246.1 NZ_LN907829:97609-97875 [Erwinia gerundensis]
MVWTINYSDRALKSLRKMDKQNARRIVDFMDLRIAAAADPRQSGKPLKGELGEFWRYRVGDYRILCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8424.36 Da        Isoelectric Point: 4.6533

>AT285791 WP_067437243.1 NZ_LN907829:97401-97625 [Erwinia gerundensis]
MLAIRLSDEIEARLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETVARVRRGDENVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U5L901

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5L7D9

References