Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 244656..245299 Replicon plasmid pEM01
Accession NZ_LN907828
Organism Erwinia gerundensis isolate E_g_EM595

Toxin (Protein)


Gene name vagD Uniprot ID A0A0U5L9X5
Locus tag EM595_RS18320 Protein ID WP_067436186.1
Coordinates 244883..245299 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0U5GSS6
Locus tag EM595_RS18315 Protein ID WP_067436183.1
Coordinates 244656..244886 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM595_RS18290 240405..240962 - 558 WP_067436169.1 hypothetical protein -
EM595_RS18295 241029..241313 - 285 WP_067436172.1 YkgJ family cysteine cluster protein -
EM595_RS18300 241310..242887 - 1578 WP_067436174.1 cobalamin adenosyltransferase -
EM595_RS18305 242901..243986 - 1086 WP_067436177.1 chemotaxis protein -
EM595_RS18315 244656..244886 + 231 WP_067436183.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EM595_RS18320 244883..245299 + 417 WP_067436186.1 type II toxin-antitoxin system VapC family toxin Toxin
EM595_RS18325 245819..246898 + 1080 WP_067436189.1 mechanosensitive ion channel family protein -
EM595_RS18330 247323..248228 - 906 WP_067436192.1 LysR family transcriptional regulator -
EM595_RS18335 248399..249454 + 1056 WP_067436195.1 aldo/keto reductase -
EM595_RS18340 249533..249826 + 294 WP_067436198.1 DUF1330 domain-containing protein -
EM595_RS21200 250161..250250 + 90 WP_157883936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iucC / iutA 1..571293 571293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-122)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15248.71 Da        Isoelectric Point: 6.4720

>T285790 WP_067436186.1 NZ_LN907828:244883-245299 [Erwinia gerundensis]
VNKTFMLDTNICSFIMREQPEAVIRRLVQTVLHNHRIVVSAITYAEMRFGTINKKASPRHAQMVDAFCARLDSILPWDQT
AVDATMEIKAALATLGTPIGPNDTAIAGHAIAVQAILVTNNIREFEGVCGLMLEDWVN

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8780.94 Da        Isoelectric Point: 4.6461

>AT285790 WP_067436183.1 NZ_LN907828:244656-244886 [Erwinia gerundensis]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIIREGDRIILRPVRPTWGSFKELAKADADFMADREDVISDEGRFDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U5L9X5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5GSS6

References