Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1898069..1898979 Replicon chromosome
Accession NZ_LN907827
Organism Erwinia gerundensis isolate E_g_EM595

Toxin (Protein)


Gene name - Uniprot ID A0A0U5GLI6
Locus tag EM595_RS08810 Protein ID WP_067430520.1
Coordinates 1898509..1898979 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0U5L5R0
Locus tag EM595_RS08805 Protein ID WP_067430517.1
Coordinates 1898069..1898512 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM595_RS08785 1894115..1894672 + 558 WP_067430506.1 non-canonical purine NTP pyrophosphatase -
EM595_RS08790 1894672..1895469 + 798 WP_067430508.1 SIR2 family protein -
EM595_RS08795 1895503..1896333 - 831 WP_067430511.1 class I SAM-dependent methyltransferase -
EM595_RS08800 1896339..1897547 - 1209 WP_067430514.1 YcaO-like family protein -
EM595_RS08805 1898069..1898512 + 444 WP_067430517.1 DUF2384 domain-containing protein Antitoxin
EM595_RS08810 1898509..1898979 + 471 WP_067430520.1 RES family NAD+ phosphorylase Toxin
EM595_RS08815 1899032..1900438 - 1407 WP_067430523.1 GABA permease -
EM595_RS08820 1900517..1901803 - 1287 WP_067430526.1 4-aminobutyrate--2-oxoglutarate transaminase -
EM595_RS08825 1901912..1903402 + 1491 WP_187487664.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-144)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17103.36 Da        Isoelectric Point: 5.5353

>T285788 WP_067430520.1 NZ_LN907827:1898509-1898979 [Erwinia gerundensis]
VKLYRLTKTRYLSSAWSGYGAREGGGRWNNVGVSMVYASETASLTMLEILVHLQSAATLDAYTLLCVEVPDGLIQWIDVT
QLPENWRAAEAPAALREIGDAWISSGESVALRIPSALSPVEHNFLLNPDHPAFTELASRASHIPFMFDSRFGTAHS

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16548.93 Da        Isoelectric Point: 8.5975

>AT285788 WP_067430517.1 NZ_LN907827:1898069-1898512 [Erwinia gerundensis]
MKQFTLPASHNTPERLWQVAGLNSADGVMLMGQIDRGLEGAVANRIISWALMTQADLRHVTGIPATTFNRGMKDRFTAEQ
SERLVRFIRVMDRAVELFEGDKHKAQQWLNEPARALDNKKPADLVSSETGAYEVLKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U5GLI6

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5L5R0

References