Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2732584..2734100 Replicon chromosome
Accession NZ_LN890477
Organism Achromobacter xylosoxidans isolate R8

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag BN2910_RS12845 Protein ID WP_155872213.1
Coordinates 2732838..2734100 (+) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag BN2910_RS12840 Protein ID WP_020926185.1
Coordinates 2732584..2732841 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN2910_RS12830 2728826..2730229 + 1404 WP_054472645.1 DKNYY domain-containing protein -
BN2910_RS12835 2730431..2732320 + 1890 WP_155872211.1 molecular chaperone HtpG -
BN2910_RS12840 2732584..2732841 + 258 WP_020926185.1 helix-turn-helix transcriptional regulator Antitoxin
BN2910_RS12845 2732838..2734100 + 1263 WP_155872213.1 type II toxin-antitoxin system HipA family toxin Toxin
BN2910_RS12850 2734298..2735497 + 1200 WP_006385726.1 MFS transporter -
BN2910_RS12855 2735501..2737684 - 2184 WP_155872215.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-75)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45593.96 Da        Isoelectric Point: 7.0530

>T285768 WP_155872213.1 NZ_LN890477:2732838-2734100 [Achromobacter xylosoxidans]
MSTDALDLYQADRKVGRLFDERPLRFVYDDAWLGWPAAHAIAPDIPLRDGAHVGEAVHAFFDNLLPEGRLRRFLQVSRHA
TTVFGLLRSVGGDTASGLTIWPQGERPAPPRYRGTTWGEIVARLQDPAQPALVAENADGARISLAGAQDKLLLMVMPDGS
PAWPEGAAPSTHILKPDIRGFDGVWSSALNETLVMQLAARLGLGVAEAGLQPDTRACLVTRYDRAPDGAGGLLRLHQLDL
CQLAGKSSDVKYEADGGPSLAHCRELLRGMGINAADLKRFLQWVLFNLCVGNNDSHAKNLSVLQTPDGQYRLAPFYDLMC
TALYPGLARNFAFAVGGESRPGHIGRGHLDAMARELGFSPRYVAGMAQALVTELPSALETVQADLARQAMAGTESTLVER
LGQWIRANTRKHAKRWELAG

Download         Length: 1263 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9117.63 Da        Isoelectric Point: 8.8566

>AT285768 WP_020926185.1 NZ_LN890477:2732584-2732841 [Achromobacter xylosoxidans]
MPSLSTADGLPIVIHTSAELGELVKDVRRAQGLLQTDLAGLSGTGNRFVVDLERGKPTLQLQKVLDMLDLLGLEVRVGPK
RVGRS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References