Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2924528..2925221 Replicon chromosome
Accession NZ_LN885086
Organism Candidatus Nitrospira inopinata isolate ENR4

Toxin (Protein)


Gene name tad Uniprot ID A0A0S4KXS0
Locus tag NITINOP_RS13820 Protein ID WP_062486960.1
Coordinates 2924528..2924905 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0S4KX63
Locus tag NITINOP_RS13825 Protein ID WP_062486962.1
Coordinates 2924886..2925221 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NITINOP_RS13795 2920399..2921130 - 732 WP_158023434.1 relaxase/mobilization nuclease domain-containing protein -
NITINOP_RS13800 2921379..2921936 - 558 WP_062486952.1 plasmid mobilization relaxosome protein MobC -
NITINOP_RS13805 2922248..2923063 + 816 WP_062486954.1 hypothetical protein -
NITINOP_RS13810 2923152..2923580 - 429 WP_062486956.1 hypothetical protein -
NITINOP_RS13815 2923644..2923886 - 243 WP_062486958.1 hypothetical protein -
NITINOP_RS13820 2924528..2924905 + 378 WP_062486960.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NITINOP_RS13825 2924886..2925221 + 336 WP_062486962.1 helix-turn-helix domain-containing protein Antitoxin
NITINOP_RS13835 2927582..2928175 - 594 WP_062486965.1 XTP/dITP diphosphatase -
NITINOP_RS13840 2928186..2928908 - 723 WP_173644432.1 ribonuclease PH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2849837..2927195 77358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14017.12 Da        Isoelectric Point: 9.9484

>T285756 WP_062486960.1 NZ_LN885086:2924528-2924905 [Candidatus Nitrospira inopinata]
MGRQERPLEWIGSSYKDLMALPVAVRRFFGYALSLAQAGDQHDDAKVLTGFGSAGVLEVVEDDRSGTYRAVYTVKFKEAV
FVLHCFQKKSKHGIATPKEDLAIIRARLKVAEALAKERRHEKTSH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12353.50 Da        Isoelectric Point: 10.5474

>AT285756 WP_062486962.1 NZ_LN885086:2924886-2925221 [Candidatus Nitrospira inopinata]
MKKRVIEGIEVFRGSGNVFADLDLPDADTLQIKTGLVIEIRRAIRQQGLTQQAAATRMGLTQPKVSSMMRGDFSNVSERK
LMECLNRLGYDIEIKVRPASARIGHLMLALP

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4KXS0

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4KX63

References