Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 920010..921394 Replicon chromosome
Accession NZ_LN885086
Organism Candidatus Nitrospira inopinata isolate ENR4

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag NITINOP_RS04360 Protein ID WP_162264691.1
Coordinates 920010..920783 (-) Length 258 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A0S4KQ95
Locus tag NITINOP_RS04365 Protein ID WP_062483640.1
Coordinates 920780..921394 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NITINOP_RS04355 916821..919883 - 3063 WP_197549211.1 type I restriction endonuclease subunit R -
NITINOP_RS04360 920010..920783 - 774 WP_162264691.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NITINOP_RS04365 920780..921394 - 615 WP_062483640.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
NITINOP_RS04370 921962..922462 - 501 WP_062483643.1 DUF4411 family protein -
NITINOP_RS04375 922459..923613 - 1155 WP_062483645.1 ImmA/IrrE family metallo-endopeptidase -
NITINOP_RS04380 923783..924070 - 288 WP_062483647.1 GIY-YIG nuclease family protein -
NITINOP_RS04385 924218..925531 - 1314 WP_162264692.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(42-233)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(12-58)


Sequences

Toxin        


Download         Length: 258 a.a.        Molecular weight: 29082.35 Da        Isoelectric Point: 9.6494

>T285754 WP_162264691.1 NZ_LN885086:c920783-920010 [Candidatus Nitrospira inopinata]
VTRKSVKDVAASVRQCLLNRSRERGEDFPLTLIYYALERLRYRLSRSAARERFVLKGAMVFSVWSGTPQRATRDLNLLRK
GSNDVAALVKEFQEICRTPVEDDGLKFLADSITGEEIRDGEEYQGVRLSFEARLGVARIPIQVDIGFGDVVLPKPVFLTY
PTLLDFPAPRLLAYPRETVIAEKFQSMVELGIANSRTKDFFDLWSLTRQFGFDGADLTQAIRGSFERRRMPLPTVSPVCL
TEDFGAIRTSRHNGRAS

Download         Length: 774 bp

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 23386.32 Da        Isoelectric Point: 11.0406

>AT285754 WP_062483640.1 NZ_LN885086:c921394-920780 [Candidatus Nitrospira inopinata]
VATKSNKSKTQQVLDIARQLKVIRTRDLTHRGIPPVYLRRLYQRGLLQQFSRGLYVLPEGDQTEHHHLAQACKRIPQGVV
CLLSALRFHGLTTQAPFEIWLAIDQKSRAPKKAHPPLRIVRMSGTTLKSGVEQHNIENVPVRVFSQAKTVADCFKFRNKI
GLDVALEALRDYRRKHRGGMDELWRYAKICRVTAVMRPYLEATA

Download         Length: 615 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4KQ95

References