Detailed information of TA system
Overview
TA module
| Type | VII | Classification (family/domain) | HepT-MntA/HepT(toxin) |
| Location | 108465..109266 | Replicon | chromosome |
| Accession | NZ_LN885086 | ||
| Organism | Candidatus Nitrospira inopinata isolate ENR4 | ||
Toxin (Protein)
| Gene name | hepT | Uniprot ID | A0A0S4KL61 |
| Locus tag | NITINOP_RS00540 | Protein ID | WP_062481780.1 |
| Coordinates | 108853..109266 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | mntA | Uniprot ID | A0A0S4KRT4 |
| Locus tag | NITINOP_RS00535 | Protein ID | WP_062481777.1 |
| Coordinates | 108465..108860 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NITINOP_RS00505 | 104257..104601 | - | 345 | WP_062487622.1 | histidine triad nucleotide-binding protein | - |
| NITINOP_RS00510 | 104675..105340 | - | 666 | WP_082633451.1 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE | - |
| NITINOP_RS00515 | 105345..106127 | - | 783 | WP_062481766.1 | imidazole glycerol phosphate synthase subunit HisF | - |
| NITINOP_RS00520 | 106203..106928 | - | 726 | WP_062481769.1 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase | - |
| NITINOP_RS00525 | 106947..107717 | - | 771 | WP_062481772.1 | hypothetical protein | - |
| NITINOP_RS00530 | 107710..108321 | - | 612 | WP_062481774.1 | imidazole glycerol phosphate synthase subunit HisH | - |
| NITINOP_RS00535 | 108465..108860 | + | 396 | WP_062481777.1 | nucleotidyltransferase domain-containing protein | Antitoxin |
| NITINOP_RS00540 | 108853..109266 | + | 414 | WP_062481780.1 | DUF86 domain-containing protein | Toxin |
| NITINOP_RS00545 | 109578..110186 | - | 609 | WP_062481783.1 | imidazoleglycerol-phosphate dehydratase HisB | - |
| NITINOP_RS00550 | 110183..111466 | - | 1284 | WP_062481785.1 | histidinol dehydrogenase | - |
| NITINOP_RS15970 | 111463..112152 | - | 690 | WP_197549246.1 | ATP phosphoribosyltransferase | - |
| NITINOP_RS15975 | 112171..113445 | - | 1275 | WP_062481788.1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15420.82 Da Isoelectric Point: 7.1078
>T285753 WP_062481780.1 NZ_LN885086:108853-109266 [Candidatus Nitrospira inopinata]
MADDVILNKAASIERCLRRIEQEYAGAEQNLIGNQTKQDAIILNLQRACETAIDLAMYVVSRRKLGVPQDSRDAFSLLHT
AGILPEDLATRMQRMVGFRNVAIHEYTRLNLEIVQAIITKQLDDFRSFSATIVKVCA
MADDVILNKAASIERCLRRIEQEYAGAEQNLIGNQTKQDAIILNLQRACETAIDLAMYVVSRRKLGVPQDSRDAFSLLHT
AGILPEDLATRMQRMVGFRNVAIHEYTRLNLEIVQAIITKQLDDFRSFSATIVKVCA
Download Length: 414 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14860.99 Da Isoelectric Point: 5.2939
>AT285753 WP_062481777.1 NZ_LN885086:108465-108860 [Candidatus Nitrospira inopinata]
MDDAKLIDYVRRAIPGLIALYRFGSQVKGAGRSDSDVDLAVLARDPIPNLRRFELAQELAVRLHRDVDLVDLRAASTVMR
MQVISTGECLDVPDESARRAFEMYVYSDYARLNEERREILKRIGESGLVYG
MDDAKLIDYVRRAIPGLIALYRFGSQVKGAGRSDSDVDLAVLARDPIPNLRRFELAQELAVRLHRDVDLVDLRAASTVMR
MQVISTGECLDVPDESARRAFEMYVYSDYARLNEERREILKRIGESGLVYG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0S4KL61 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0S4KRT4 |