Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4894543..4896233 Replicon chromosome
Accession NZ_LN879547
Organism Comamonas thiooxydans isolate C19

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BN2297_RS22265 Protein ID WP_057094001.1
Coordinates 4895355..4896233 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BN2297_RS22260 Protein ID WP_057093999.1
Coordinates 4894543..4895349 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN2297_RS22240 4890535..4891311 - 777 WP_057093991.1 SDR family oxidoreductase -
BN2297_RS22245 4891628..4892386 - 759 WP_057093992.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
BN2297_RS22250 4892507..4893493 - 987 WP_057093994.1 tripartite tricarboxylate transporter substrate binding protein -
BN2297_RS22255 4893700..4894500 - 801 WP_057093996.1 aspartate dehydrogenase -
BN2297_RS22260 4894543..4895349 - 807 WP_057093999.1 IclR family transcriptional regulator Antitoxin
BN2297_RS22265 4895355..4896233 - 879 WP_057094001.1 alpha/beta hydrolase Toxin
BN2297_RS22270 4896242..4896775 - 534 WP_057094003.1 cupin domain-containing protein -
BN2297_RS22275 4897035..4898711 - 1677 WP_057094005.1 long-chain-fatty-acid--CoA ligase -
BN2297_RS22280 4898925..4899989 - 1065 WP_004340312.1 fructose-bisphosphate aldolase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-277)

Antitoxin

Transcription regulator IclR, C-terminal

(137-257)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30598.03 Da        Isoelectric Point: 6.0748

>T285752 WP_057094001.1 NZ_LN879547:c4896233-4895355 [Comamonas thiooxydans]
MHEDLLSLKLQLLQTGFPERLVKLPQDAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLADKVRVLAWDAPGYGV
STPLAQSAPADADYAHALAQSLLVLGVRRCILVGHSLGALMAARLAVTAAPGLVEQLVLISPAGGYGAAAKAEQQAKVRE
GRLAALADKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQAQGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS

Download         Length: 879 bp

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29285.26 Da        Isoelectric Point: 5.1709

>AT285752 WP_057093999.1 NZ_LN879547:c4895349-4894543 [Comamonas thiooxydans]
MSETPEISTNEQDRYTVPALDRGLRLLACFGPTQPVWSAPELARKLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNVDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGQVVAGLGMAIPFTELGPEK
TQLWVQKVQEAAETLSAHLRQQHPDHLR

Download         Length: 807 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References