Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2343443..2344044 Replicon chromosome
Accession NZ_LN879547
Organism Comamonas thiooxydans isolate C19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BN2297_RS10550 Protein ID WP_019042333.1
Coordinates 2343443..2343829 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A076PMR1
Locus tag BN2297_RS10555 Protein ID WP_034356765.1
Coordinates 2343829..2344044 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN2297_RS10535 2340910..2342220 - 1311 WP_034356769.1 DNA polymerase Y family protein -
BN2297_RS10540 2342165..2342965 - 801 WP_122974731.1 translesion DNA synthesis-associated protein ImuA -
BN2297_RS10545 2343145..2343354 - 210 WP_034356767.1 hypothetical protein -
BN2297_RS10550 2343443..2343829 - 387 WP_019042333.1 twitching motility protein PilT Toxin
BN2297_RS10555 2343829..2344044 - 216 WP_034356765.1 DUF2191 domain-containing protein Antitoxin
BN2297_RS10560 2344129..2344946 + 818 Protein_2091 SprT-like domain-containing protein -
BN2297_RS10565 2345100..2345426 + 327 WP_019042331.1 transposase -
BN2297_RS26040 2345769..2346674 - 906 Protein_2093 phosphoethanolamine transferase -
BN2297_RS26045 2347688..2348077 + 390 WP_080571250.1 CzcE family metal-binding protein -
BN2297_RS26050 2348157..2348603 - 447 WP_019042328.1 Cd(II)/Pb(II)-responsive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2208970..2715678 506708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13999.29 Da        Isoelectric Point: 5.0594

>T285751 WP_019042333.1 NZ_LN879547:c2343829-2343443 [Comamonas thiooxydans]
MPVSVLVDTSVWVRHFREADTHLQELLMQDSVLMHSMVHAELACGTPPAPRADTLAALAMLRPSQEASIPETLEFLEQNK
LFGKGCGLVDLSLLASTLITPGALLWTADRRLADMATQLNVAYLPPLH

Download         Length: 387 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7519.50 Da        Isoelectric Point: 5.0166

>AT285751 WP_034356765.1 NZ_LN879547:c2344044-2343829 [Comamonas thiooxydans]
MRSTFTIDDDVVNRARAVAAPGIAVPELVRLALETFTRVEAGKRLAALGGAAPNMPDVPRRGSEADAEDSR

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076PMR1

References