Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2239893..2241453 Replicon chromosome
Accession NZ_LN879547
Organism Comamonas thiooxydans isolate C19

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag BN2297_RS10060 Protein ID WP_057092262.1
Coordinates 2240143..2241453 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag BN2297_RS10055 Protein ID WP_057092261.1
Coordinates 2239893..2240153 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN2297_RS10040 2236593..2237468 + 876 WP_057092259.1 hypothetical protein -
BN2297_RS10045 2237561..2239399 + 1839 WP_057092260.1 dihydrolipoyl dehydrogenase -
BN2297_RS10050 2239546..2239716 + 171 WP_100086418.1 aldehyde-activating protein -
BN2297_RS10055 2239893..2240153 + 261 WP_057092261.1 helix-turn-helix transcriptional regulator Antitoxin
BN2297_RS10060 2240143..2241453 + 1311 WP_057092262.1 type II toxin-antitoxin system HipA family toxin Toxin
BN2297_RS10065 2241689..2242165 + 477 WP_081033953.1 GFA family protein -
BN2297_RS10070 2242302..2243672 - 1371 WP_081033954.1 MFS transporter -
BN2297_RS10075 2244442..2244798 - 357 WP_046462443.1 alkylphosphonate utilization protein -
BN2297_RS10080 2244994..2245905 - 912 WP_057092264.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2208970..2715678 506708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-60)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 47415.58 Da        Isoelectric Point: 8.0922

>T285750 WP_057092262.1 NZ_LN879547:2240143-2241453 [Comamonas thiooxydans]
MTSKSTHELEVWLFDGRVGSLSLVHGRLSFAYAIDWLALPQATALSQSLPLQAKPFDDHQTRPFFAGLLPEGQMRRLIAQ
QFQVSGQNDFALLDHIGGECAGAVTFLEPGQALPQTNGAGATGAPGDVDWLSDQKLLALLDELPRRPMLAGDDGLRLSLA
GAQDKLPVVVDESIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRY
DRELNAQDLHQPQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALLRSVTRPSAPQVLRLLDGAIFNALIGNHDAHG
KNFSLLYGGRAPVLAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATRKRLQQLANELPAAA
RKLQAAPPHGFAGNAVVKQIVQLIEQRCTLTLRRLA

Download         Length: 1311 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8959.15 Da        Isoelectric Point: 4.5007

>AT285750 WP_057092261.1 NZ_LN879547:2239893-2240153 [Comamonas thiooxydans]
MSTIQTTEQLGAALRTARKQLGLTQPQLALAAGVGTRFIVDLEAGKPTVRLEHVLRVIDALGGELQLGGLPDTDSEGVAE
GADHDV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References