285740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4718250..4718858 Replicon chromosome
Accession NZ_LN871187
Organism Pseudomonas aeruginosa strain PAO1_Orsay

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag PAO1OR_RS21760 Protein ID WP_003114156.1
Coordinates 4718250..4718597 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PAO1OR_RS29600 Protein ID WP_003114155.1
Coordinates 4718607..4718858 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAO1OR_RS21730 4713609..4713881 + 273 WP_010895521.1 cysteine-rich CWC family protein -
PAO1OR_RS21735 4713881..4714573 + 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
PAO1OR_RS21740 4714709..4715752 + 1044 WP_003098363.1 L,D-transpeptidase -
PAO1OR_RS21745 4715832..4716569 + 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
PAO1OR_RS21750 4717021..4717923 + 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PAO1OR_RS21760 4718250..4718597 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAO1OR_RS29600 4718607..4718858 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PAO1OR_RS21765 4719072..4720055 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
PAO1OR_RS21770 4720055..4721347 - 1293 WP_003115206.1 hypothetical protein -
PAO1OR_RS21775 4721577..4722851 - 1275 WP_010895520.1 zonular occludens toxin family protein -
PAO1OR_RS21780 4722855..4723211 - 357 WP_003114150.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4718250..4740420 22170


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T285740 WP_003114156.1 NZ_LN871187:c4718597-4718250 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT285740 WP_003114155.1 NZ_LN871187:c4718858-4718607 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References