Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4398455..4399713 Replicon chromosome
Accession NZ_LN871187
Organism Pseudomonas aeruginosa strain PAO1_Orsay

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PAO1OR_RS20170 Protein ID WP_003112528.1
Coordinates 4398455..4399210 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PAO1OR_RS20175 Protein ID WP_003086329.1
Coordinates 4399345..4399713 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAO1OR_RS20160 4393628..4396171 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PAO1OR_RS20165 4396326..4397687 - 1362 WP_010895536.1 DNA recombination protein RmuC -
PAO1OR_RS20170 4398455..4399210 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PAO1OR_RS20175 4399345..4399713 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PAO1OR_RS20180 4399786..4401072 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
PAO1OR_RS20185 4401128..4402717 - 1590 WP_010895535.1 aldehyde dehydrogenase family protein -
PAO1OR_RS20190 4402796..4403272 + 477 WP_003112531.1 hypothetical protein -
PAO1OR_RS29970 4403275..4403550 - 276 WP_010793902.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T285739 WP_003112528.1 NZ_LN871187:c4399210-4398455 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT285739 WP_003086329.1 NZ_LN871187:c4399713-4399345 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References