Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3466051..3467272 Replicon chromosome
Accession NZ_LN871187
Organism Pseudomonas aeruginosa strain PAO1_Orsay

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PAO1OR_RS15815 Protein ID WP_003114949.1
Coordinates 3466694..3467272 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PAO1OR_RS15810 Protein ID WP_003088112.1
Coordinates 3466051..3466605 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAO1OR_RS15785 3461619..3462170 + 552 WP_003102727.1 XRE family transcriptional regulator -
PAO1OR_RS15790 3462167..3462565 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PAO1OR_RS15795 3462578..3462901 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PAO1OR_RS15800 3463232..3463693 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PAO1OR_RS15805 3463698..3465893 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PAO1OR_RS15810 3466051..3466605 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
PAO1OR_RS15815 3466694..3467272 + 579 WP_003114949.1 HD domain-containing protein Toxin
PAO1OR_RS15820 3467380..3468567 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PAO1OR_RS15825 3468557..3470728 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PAO1OR_RS15830 3470718..3471995 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T285738 WP_003114949.1 NZ_LN871187:3466694-3467272 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT285738 WP_003088112.1 NZ_LN871187:3466051-3466605 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References