Detailed information of TA system TA285738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3466051..3467272
• Replicon: chromosome
• Accession: NZ_LN871187
• Organism: Pseudomonas aeruginosa strain PAO1_Orsay

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: PAO1OR_RS15815
• Protein ID: WP_003114949.1
• Coordinates: 3466694..3467272 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: PAO1OR_RS15810
• Protein ID: WP_003088112.1
• Coordinates: 3466051..3466605 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAO1OR_RS15785	3461619..3462170	+	552	WP_003102727.1	XRE family transcriptional regulator	-
PAO1OR_RS15790	3462167..3462565	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
PAO1OR_RS15795	3462578..3462901	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
PAO1OR_RS15800	3463232..3463693	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
PAO1OR_RS15805	3463698..3465893	+	2196	WP_003114948.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
PAO1OR_RS15810	3466051..3466605	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
PAO1OR_RS15815	3466694..3467272	+	579	WP_003114949.1	HD domain-containing protein	Toxin
PAO1OR_RS15820	3467380..3468567	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
PAO1OR_RS15825	3468557..3470728	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
PAO1OR_RS15830	3470718..3471995	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21897.75 Da
• Isoelectric Point: 5.3655

>T285738 WP_003114949.1 NZ_LN871187:3466694-3467272 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Nucleotide

• Length: 579 bp

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT285738 WP_003088112.1 NZ_LN871187:3466051-3466605 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp