Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4357950..4359207 Replicon chromosome
Accession NZ_LN870292
Organism Pseudomonas aeruginosa DK1 substr. NH57388A

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PADK1_RS20585 Protein ID WP_003449003.1
Coordinates 4357950..4358705 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PADK1_RS20590 Protein ID WP_003086329.1
Coordinates 4358839..4359207 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PADK1_RS20575 4353123..4355666 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
PADK1_RS20580 4355821..4357182 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PADK1_RS20585 4357950..4358705 - 756 WP_003449003.1 RES family NAD+ phosphorylase Toxin
PADK1_RS20590 4358839..4359207 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PADK1_RS20595 4359280..4360566 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
PADK1_RS20600 4360622..4362211 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PADK1_RS20605 4362290..4362766 + 477 WP_003112531.1 hypothetical protein -
PADK1_RS29485 4362769..4363044 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28292.45 Da        Isoelectric Point: 7.7294

>T285733 WP_003449003.1 NZ_LN870292:c4358705-4357950 [Pseudomonas aeruginosa DK1]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT285733 WP_003086329.1 NZ_LN870292:c4359207-4358839 [Pseudomonas aeruginosa DK1]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References