Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3437209..3438430 Replicon chromosome
Accession NZ_LN870292
Organism Pseudomonas aeruginosa DK1 substr. NH57388A

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PADK1_RS16145 Protein ID WP_003102740.1
Coordinates 3437852..3438430 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PADK1_RS16140 Protein ID WP_033887039.1
Coordinates 3437209..3437763 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PADK1_RS16115 3432778..3433329 + 552 WP_003102727.1 XRE family transcriptional regulator -
PADK1_RS16120 3433326..3433724 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PADK1_RS16125 3433737..3434060 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PADK1_RS16130 3434391..3434852 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PADK1_RS16135 3434857..3437052 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PADK1_RS16140 3437209..3437763 + 555 WP_033887039.1 helix-turn-helix transcriptional regulator Antitoxin
PADK1_RS16145 3437852..3438430 + 579 WP_003102740.1 HD domain-containing protein Toxin
PADK1_RS16150 3438539..3439726 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PADK1_RS16155 3439716..3441887 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PADK1_RS16160 3441877..3443154 - 1278 WP_034009214.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T285732 WP_003102740.1 NZ_LN870292:3437852-3438430 [Pseudomonas aeruginosa DK1]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20426.58 Da        Isoelectric Point: 8.1590

>AT285732 WP_033887039.1 NZ_LN870292:3437209-3437763 [Pseudomonas aeruginosa DK1]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGAPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References