Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 584534..585204 Replicon chromosome
Accession NZ_LN868938
Organism Nocardia farcinica strain NCTC11134

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H5NFP9
Locus tag AMO33_RS03015 Protein ID WP_060590342.1
Coordinates 584534..584950 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0H5NWG5
Locus tag AMO33_RS03020 Protein ID WP_060590344.1
Coordinates 584947..585204 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMO33_RS02990 579896..580585 - 690 WP_011209958.1 cyclodeaminase/cyclohydrolase family protein -
AMO33_RS02995 580713..581750 + 1038 WP_060590338.1 LLM class F420-dependent oxidoreductase -
AMO33_RS03000 581819..582157 - 339 WP_011209956.1 STAS domain-containing protein -
AMO33_RS03005 582842..583246 - 405 WP_197657723.1 MarR family transcriptional regulator -
AMO33_RS03010 583336..584061 + 726 WP_060590340.1 glucose 1-dehydrogenase -
AMO33_RS03015 584534..584950 - 417 WP_060590342.1 type II toxin-antitoxin system VapC family toxin Toxin
AMO33_RS03020 584947..585204 - 258 WP_060590344.1 hypothetical protein Antitoxin
AMO33_RS03025 585735..586376 - 642 WP_060590346.1 LysE family translocator -
AMO33_RS03030 586653..587189 - 537 WP_011209949.1 hypothetical protein -
AMO33_RS03035 587233..588621 - 1389 WP_011209948.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14982.91 Da        Isoelectric Point: 4.4227

>T285724 WP_060590342.1 NZ_LN868938:c584950-584534 [Nocardia farcinica]
VIILDTNVISEPTTKAPDERVMAWLDAQVSETLYLSAVTVGELRYGIATMPSGRRRDEFTDWLENHTLPAFTGRILAYDL
NATTEYARLMSQARAQGLAIAVADGMIAATAAAAGFAVATRDRSPFEAADVPTIDPWH

Download         Length: 417 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9680.92 Da        Isoelectric Point: 5.7316

>AT285724 WP_060590344.1 NZ_LN868938:c585204-584947 [Nocardia farcinica]
MKNVTIRNLSDEVHRAIRQRAAANERSIEAEMRAILTEAVKPTERTKIGTLLAGVISEESRLTDDERDIYFGRDQTPHEP
MVFGQ

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H5NFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H5NWG5

References