Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1840156..1841792 Replicon chromosome
Accession NZ_LN868200
Organism Acinetobacter baumannii isolate R2090

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ABR2090_RS08830 Protein ID WP_000737057.1
Coordinates 1840156..1841487 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ABR2090_RS08835 Protein ID WP_001101309.1
Coordinates 1841484..1841792 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABR2090_RS08805 1835238..1836476 + 1239 WP_104130960.1 TolC family protein -
ABR2090_RS08810 1836469..1837632 + 1164 WP_001044484.1 hypothetical protein -
ABR2090_RS08815 1837758..1838729 + 972 WP_086223204.1 5'/3'-nucleotidase SurE -
ABR2090_RS08820 1838741..1839385 + 645 WP_000817313.1 hypothetical protein -
ABR2090_RS08825 1839420..1839860 - 441 WP_000193129.1 HD domain-containing protein -
ABR2090_RS08830 1840156..1841487 + 1332 WP_000737057.1 type II toxin-antitoxin system HipA family toxin Toxin
ABR2090_RS08835 1841484..1841792 + 309 WP_001101309.1 helix-turn-helix domain-containing protein Antitoxin
ABR2090_RS08840 1842518..1843066 + 549 WP_043961199.1 TetR/AcrR family transcriptional regulator -
ABR2090_RS08845 1843221..1844243 + 1023 WP_000912538.1 MBL fold metallo-hydrolase -
ABR2090_RS08850 1844230..1845045 + 816 WP_058222016.1 hypothetical protein -
ABR2090_RS08855 1845075..1846007 - 933 WP_031951484.1 IS5-like element ISAba13 family transposase -
ABR2090_RS08860 1846049..1846648 + 600 WP_058222017.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1845075..1846007 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51160.29 Da        Isoelectric Point: 4.9820

>T285723 WP_000737057.1 NZ_LN868200:1840156-1841487 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCKLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11644.61 Da        Isoelectric Point: 10.1265

>AT285723 WP_001101309.1 NZ_LN868200:1841484-1841792 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPKE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References