Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1768753..1769469 Replicon chromosome
Accession NZ_LN865164
Organism Pseudomonas sp. URMO17WK12:I11 isolate Yellow

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PSHI_RS21840 Protein ID WP_080992932.1
Coordinates 1768753..1768935 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0S4I868
Locus tag PSHI_RS07995 Protein ID WP_049696767.1
Coordinates 1769023..1769469 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSHI_RS07970 1764000..1764689 + 690 WP_023535781.1 ABC transporter permease -
PSHI_RS07975 1764803..1766008 + 1206 WP_059183455.1 methyltransferase -
PSHI_RS07980 1766430..1766720 - 291 WP_059183456.1 DUF3077 domain-containing protein -
PSHI_RS07985 1767381..1767629 + 249 WP_023535804.1 hypothetical protein -
PSHI_RS21840 1768753..1768935 + 183 WP_080992932.1 type II toxin-antitoxin system HicA family toxin Toxin
PSHI_RS07995 1769023..1769469 + 447 WP_049696767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PSHI_RS08000 1769767..1770924 - 1158 WP_050587302.1 HAMP domain-containing histidine kinase -
PSHI_RS08005 1770917..1771729 - 813 WP_059183457.1 alpha/beta hydrolase -
PSHI_RS08010 1772067..1772273 + 207 WP_023535792.1 DUF3079 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6809.81 Da        Isoelectric Point: 11.4650

>T285719 WP_080992932.1 NZ_LN865164:1768753-1768935 [Pseudomonas sp. URMO17WK12:I11]
VHSRDIIKRLKDDGWVRVKGTDGSHQQFKHPTKKGRVTVPHPNKDVATGTLRNIWKQAGL

Download         Length: 183 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16381.38 Da        Isoelectric Point: 4.3924

>AT285719 WP_049696767.1 NZ_LN865164:1769023-1769469 [Pseudomonas sp. URMO17WK12:I11]
MKYPVVLHKDEDSDYGVTVPDVPGCFSAGETIDEALSEVQLALEMHFEGLVEDGEPLPQPQNIEIHRKDPAYADGIWAFV
EFDVTPYYGKSVRFNASLPEGLLKRIDDRVKEDSAYASRSGFLAAAALHELAKNLNEGIDALKTRKTV

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4I868

References