Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 2488500..2489131 Replicon chromosome
Accession NZ_LN854573
Organism Pseudomonas sp. URMO17WK12:I11 isolate Shine

Toxin (Protein)


Gene name mazF Uniprot ID A0A0S4HTM0
Locus tag AWM52_RS11270 Protein ID WP_059181764.1
Coordinates 2488500..2488862 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0S4HTP8
Locus tag AWM52_RS11275 Protein ID WP_059181765.1
Coordinates 2488862..2489131 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWM52_RS11260 2483631..2486981 + 3351 WP_027922063.1 mechanosensitive channel MscK -
AWM52_RS11265 2487030..2488493 + 1464 WP_059181763.1 YdiU family protein -
AWM52_RS11270 2488500..2488862 - 363 WP_059181764.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AWM52_RS11275 2488862..2489131 - 270 WP_059181765.1 hypothetical protein Antitoxin
AWM52_RS11280 2489402..2489836 + 435 WP_027922067.1 thioredoxin TrxC -
AWM52_RS11285 2489967..2490737 - 771 WP_027922068.1 ParA family protein -
AWM52_RS11290 2491093..2491818 + 726 WP_059181766.1 beta-ketoacyl synthase chain length factor -
AWM52_RS11295 2491794..2492603 + 810 WP_027922070.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
AWM52_RS11300 2492584..2492844 + 261 WP_027922071.1 acyl carrier protein -
AWM52_RS11305 2492854..2493108 + 255 WP_007947135.1 acyl carrier protein -
AWM52_RS11310 2493105..2493650 + 546 WP_027922072.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13042.82 Da        Isoelectric Point: 6.4595

>T285714 WP_059181764.1 NZ_LN854573:c2488862-2488500 [Pseudomonas sp. URMO17WK12:I11]
MVRGQAPQRGDVYWVDPNPVAGREMMSRHRFVVITPREINALGVSMTVPITSGGSFSRNSGLAVVVSGHDTTGVAVCNQV
RSFDIEQRVRDGSAKFIERLDDVTMADIVARVVSSIDPLD

Download         Length: 363 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9519.00 Da        Isoelectric Point: 5.8336

>AT285714 WP_059181765.1 NZ_LN854573:c2489131-2488862 [Pseudomonas sp. URMO17WK12:I11]
MSVTSKIRRQGGAAVITLPPTLLKLLHLEVGAQLELNVVNGELIARPVVPSSRKRYSLTELLEGAEEMAELNALTSSARE
GDPVGRELG

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4HTM0

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4HTP8

References