28571

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/Peptidase_M78-HTH_19
Location 2408863..2409557 Replicon chromosome
Accession NC_019770
Organism Enterococcus faecalis str. Symbioflor 1

Toxin (Protein)


Gene name IrrE Uniprot ID A0A828QV40
Locus tag EFS1_RS12210 Protein ID WP_002406159.1
Coordinates 2409213..2409557 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID A0A828QTI6
Locus tag EFS1_RS12205 Protein ID WP_002406160.1
Coordinates 2408863..2409195 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFS1_RS12160 2404367..2405155 - 789 WP_002406165.1 DnaD domain protein -
EFS1_RS12165 2405171..2405958 - 788 Protein_2305 PD-(D/E)XK nuclease-like domain-containing protein -
EFS1_RS12170 2405921..2406892 - 972 WP_015212255.1 recombinase RecT -
EFS1_RS12180 2406995..2407219 - 225 WP_002370012.1 hypothetical protein -
EFS1_RS12185 2407216..2407515 - 300 WP_002406162.1 hypothetical protein -
EFS1_RS12190 2407602..2408018 - 417 WP_002370016.1 hypothetical protein -
EFS1_RS14800 2408212..2408355 - 144 WP_002393055.1 hypothetical protein -
EFS1_RS12200 2408366..2408542 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
EFS1_RS12205 2408863..2409195 + 333 WP_002406160.1 helix-turn-helix domain-containing protein Antitoxin
EFS1_RS12210 2409213..2409557 + 345 WP_002406159.1 ImmA/IrrE family metallo-endopeptidase Toxin
EFS1_RS12215 2409627..2410076 + 450 WP_002406158.1 hypothetical protein -
EFS1_RS12220 2410186..2411553 + 1368 WP_002406157.1 recombinase family protein -
EFS1_RS12225 2411575..2412150 - 576 WP_002393061.1 DNA repair protein RadC -
EFS1_RS12230 2412182..2412841 - 660 WP_002398690.1 HAD family hydrolase -
EFS1_RS12235 2412825..2414147 - 1323 WP_002410879.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2368853..2412126 43273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(24-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13556.36 Da        Isoelectric Point: 4.9882

>T28571 WP_002406159.1 NC_019770:2409213-2409557 [Enterococcus faecalis str. Symbioflor 1]
MKSIKELVEEYNVELVFTTLHKKACFESEHGVIFVNQNLSTEEQEEAIYHEFKHVKDHADLMALYNIPIFRSKMEAEAEH
YMFECLIEKNDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

>T28571 NC_019770:2409213-2409557 [Enterococcus faecalis str. Symbioflor 1]
ATGAAAAGTATCAAAGAGTTGGTTGAAGAATATAATGTGGAGTTGGTCTTTACTACATTACACAAAAAAGCTTGCTTCGA
ATCAGAACATGGTGTGATTTTTGTTAATCAAAATTTATCTACTGAAGAACAAGAAGAAGCAATTTATCATGAATTTAAGC
ACGTGAAAGATCATGCTGATTTGATGGCACTATACAACATCCCTATTTTTAGATCAAAAATGGAAGCAGAAGCTGAACAT
TATATGTTCGAATGTTTGATTGAAAAAAACGATGGTCAGTTTAATTATTCTAACGTAATTACACATTATAATTTAAAAAT
GGGGCAAGAAACTTATCTAAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12575.25 Da        Isoelectric Point: 5.2423

>AT28571 WP_002406160.1 NC_019770:2408863-2409195 [Enterococcus faecalis str. Symbioflor 1]
MTAFDRIKKITDRRGISINELENRVGISQNVLYGWKKKTPGGENLTKVAKYLNISTDYILGIVDNPEPFVEKKTDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT28571 NC_019770:2408863-2409195 [Enterococcus faecalis str. Symbioflor 1]
ATGACAGCATTTGATAGAATAAAAAAAATTACAGACCGTAGAGGTATTTCCATTAATGAGTTAGAAAATCGAGTTGGAAT
TAGTCAAAATGTATTATATGGATGGAAGAAAAAAACTCCTGGCGGTGAAAATTTGACTAAAGTTGCTAAATATTTAAATA
TTTCCACTGATTATATTTTAGGAATAGTTGATAATCCAGAACCTTTTGTCGAAAAAAAAACTGATGATTTAGACGATGTA
CTAGATAACGTCATGAGCTTTGATGGTGAACCACTTGATGATCATGACAGAGAAGTTATTCGTGCTTACTTGAAAGGAAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828QV40

Antitoxin

Source ID Structure
AlphaFold DB A0A828QTI6

References